| abstract |
The present invention discloses compounds of formulae (I) to (VIII) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein R 3 is substituted with 0 to 3 and R 1 , R 2 , R 3a , R 4 and n are defined herein. The present invention also discloses methods of using these compounds as PAR4 inhibitors and pharmaceutical compositions comprising these compounds. These compounds are useful for inhibiting or preventing platelet aggregation and for treating thromboembolic disorders or primary prevention of thromboembolic disorders. |