| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49790ed5b8ddc5fa27a1d47732c612df |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate |
2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2d9943882c1730a1c3000cfb8f3c4f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea6878e9c50b49060c958ae5a1d2c230
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b3a648796f599d9c37f515bfbf232c7 |
| publicationDate |
2019-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109680060-A |
| titleOfInvention |
Methylation markers and their applications in tumor diagnosis and classification |
| abstract |
The present invention discloses a type of methylation markers for early diagnosis of tumors. The markers include CpG islands corresponding to 248 probes in the HumanMethylation450 BeadChip Kit. The tissue is distinguished from the normal tissue adjacent to the cancer. The machine learning model constructed using the methylation levels of the markers can not only be used to clinically predict the risk of suffering from the 12 tumors in the training set, but also can be applied to other tumors and performed well in other tumors, The area under the curve reaches 0.94; it proves that the methylation level of the CpG island screened by the present invention can be used for the early diagnosis of almost all TCGA tumors. The present invention also provides CpG islands corresponding to 515 methylation markers in the HumanMethylation450BeadChip Kit for tumor classification and identification of tumor types. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112779334-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022142677-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022190752-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113817822-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111370129-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111370129-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115424666-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112779334-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112941180-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110310700-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110310700-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023078283-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020012367-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112852969-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114606316-A |
| priorityDate |
2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |