http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109679105-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G77-392 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-025 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G77-392 |
| filingDate | 2018-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109679105-B |
| titleOfInvention | Organic/inorganic hybrid material based on oligomeric silsesquioxane, preparation method and application in bone tissue engineering |
| abstract | The present invention aims at the existing organic/inorganic composite materials for hard tissue engineering. When eroded by body fluids, the macromolecular polymer is first degraded, the inorganic particles will become free nanoparticles, and the material will lose its toughness. Provided are an oligomeric silsesquioxane-based organic-inorganic hybrid material, a preparation method and its application in bone tissue engineering, belonging to the technical field of biological composite materials. The spatial structure of the hybrid material is: or A is an oligomeric silsesquioxane cage, and its general structural formula is R n Si n O 1.5n , wherein n=6, 8, 10 or 12; B is a reactive flexible arm connecting two cages. The present invention also provides a preparation method for preparing the above hybrid material by click chemistry and its use as a bone material in tissue engineering. The hybrid material constructed by the invention has simple reaction operation, mild conditions, and is insensitive to oxygen and water; the product has high yield and good selectivity; the product is easy to purify and the post-processing is simple, and the obtained material has very good mechanical properties and biological activity. . |
| priorityDate | 2018-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.