http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109678992-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F8-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F8-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F16-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 |
| filingDate | 2019-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109678992-B |
| titleOfInvention | A kind of folic acid functionalized modified polyvinyl alcohol medicinal polymer material for soluble microneedle and preparation method thereof |
| abstract | The invention discloses a folic acid-modified polyvinyl alcohol medicinal polymer material for soluble microneedles and a preparation method thereof. The specific steps of the method of the present invention are as follows: (1) at a temperature of 90 to 100° C., sodium hydroxide and solid acrylamide are added to the polyvinyl alcohol aqueous solution to carry out Michael addition reaction to obtain acrylamide-modified PVA; (2) The acrylamide-modified PVA is dissolved in deionized water, and the activated folic acid aqueous solution is added dropwise with stirring to react in the dark, and then purified by dialysis to obtain the folic acid-modified polyvinyl alcohol material. The yield of the polymer obtained by the invention is high, the obtained material has good solubility, is favorable for degradation, and the dosage is small, which can reduce the residue of the polymer in the skin after the microneedle administration. The microneedles prepared by pouring the lower polymer concentration solution into the microneedle mold have obvious needle shapes; the microneedles can penetrate the tin foil and have sufficient mechanical properties, which can be used in the transdermal drug delivery system to achieve a certain drug loading rate. preparation. |
| priorityDate | 2019-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.