http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109678752-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2018-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109678752-B |
| titleOfInvention | Method for synthesizing L-2-aminobutanamide hydrochloride by asymmetric transformation |
| abstract | The invention belongs to the field of drug synthesis, and discloses an asymmetric transformation synthesis method of L-2-aminobutanamide hydrochloride, which comprises the following steps: dissolving DL-aminobutanamide in n-butyric acid, and sequentially adding racemization agent n-butyraldehyde, L-tartaric acid and a small amount of acetic anhydride, reacting at the temperature of 115 ℃ and 125 ℃ for 8-10 hours to obtain L-aminobutanamide tartaric acid double salt; and (3) introducing hydrogen chloride gas into the L-aminobutanamide tartaric acid complex salt in ethanol, keeping the temperature at 20-30 ℃ for reaction for 4 hours, and filtering to obtain L-2-aminobutanamide hydrochloride. The method has simple process operation and environmental protection, the purity of the final product reaches 99.72 percent, the yield reaches 95.25 percent, and the method is beneficial to industrial production. |
| priorityDate | 2018-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.