| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B2235-6567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B2235-6562
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B2235-3213
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B2235-3212
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B2235-3262
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-412
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B2235-3284 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B41-83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B35-447
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B35-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B41-4807
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C04B38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C04B35-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C04B38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C04B35-447
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C04B41-83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-10 |
| filingDate |
2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109678488-B |
| titleOfInvention |
Ion-doped and protein-impregnated dual-modified porous calcium phosphate ceramic and preparation method thereof |
| abstract |
The invention belongs to the field of medical materials for repairing bone injury, and discloses ion-doped and protein-impregnated double-modified porous calcium phosphate ceramic and a preparation method thereof. The preparation method comprises the following steps: preparing calcium phosphate powder doped with bone-promoting ions, preparing ion-doped porous calcium phosphate ceramic in a pore-forming mode, then soaking the ion-doped porous calcium phosphate ceramic in a silk fibroin solution under negative pressure, and repeatedly soaking and drying to obtain the ion-doped and protein-impregnated double-modified porous calcium phosphate ceramic capable of promoting bone formation and vascularization. The invention improves the mechanical property of the porous calcium phosphate ceramic by impregnating the porous calcium phosphate ceramic with multilayer protein. The invention adopts the double modification mode of ion doping and protein dipping, improves the mechanical and biological properties of the porous calcium phosphate ceramic and has certain significance for expanding the clinical application of the porous calcium phosphate ceramic. |
| priorityDate |
2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |