http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109668988-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-74 |
| filingDate | 2019-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109668988-B |
| titleOfInvention | Method for analyzing and determining 2- (dibromomethyl) -4-fluorobenzonitrile in trelagliptin succinate |
| abstract | The invention provides a method for analyzing and determining genotoxic impurity 2- (dibromomethyl) -4-fluorobenzonitrile in trelagliptin succinate by using an HPLC method. The built high-efficiency liquid phase analysis method can accurately determine the potential genotoxic impurity 2- (dibromomethyl) -4-fluorobenzonitrile in the trelagliptin succinate by adopting octadecylsilane chemically bonded silica as a stationary phase, a phosphoric acid aqueous solution and an acetonitrile solution as mobile phases and adopting a gradient elution mode. The HPLC-UV method is simple to operate, short in analysis time, high in accuracy and good in repeatability, the sensitivity can reach 1.6ppm, a reliable detection method is provided for the quality standard of trelagliptin succinate, a guarantee is provided for the healthy medication of patients, and the method belongs to the technical field of medicines. |
| priorityDate | 2019-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.