abstract |
The present invention proposes a microorganism. The microorganism comprises: overexpressing at least one of the following genes: PAH1, DGA1, OLE1, ACC1**, ACCA2, ACCB, ACCE, DGAT, LPPĪ², OLE1A, OLE1B, OLE1C, OLE1D, EcACCA, EcACCB, EcACCC , EcACCD, pgpB, atfA, fabA, fabB; and silencing comprises at least one selected from FLD1, TGL3, wherein the microorganism is a microorganism with the potential to synthesize hydrophobic compounds. According to the embodiment of the present invention, the yield of hydrophobic compounds of microorganisms can be increased by more than 10%, for example, the yield of lycopene is increased by more than 40%, the yield of natamycin is increased by 14%, and the yield of spinosyn is increased by 20%, The yield of astaxanthin was increased by 50%, and the product was less toxic to cell growth. |