http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109666013-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 |
| filingDate | 2017-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109666013-B |
| titleOfInvention | Bipiperidine substituted isoflavone compound and use thereof |
| abstract | The invention discloses a novel bipiperidine substituted isoflavone compound I which can inhibit the activity of a cell histamine H3 receptor and the activity of a cell acetyl cholinesterase in a dose-dependent manner under a safe dose, and the compound with single molecule and multi-target activity can protect nerve cells; alleviating hypoxic injury to nerve cells; modulating neuroinflammation; has strong inhibition effect on histamine H3 receptor and activity of acetyl cholinesterase and butyryl cholinesterase; animal experiment results prove that the compound I has lower toxicity, can permeate blood brain barrier and can obviously permeate blood brain barrierImproving mouse dementia caused by scopolamine, and enhancing learning and memory functions. The compound I is expected to be a drug for preventing and/or treating learning and memory disorders and Alzheimer's disease, vascular dementia, Parkinson's disease, Huntington's disease, etc. |
| priorityDate | 2017-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 153.