http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109666010-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1139562b85064a01a57a7fd052ebfd57 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-58 |
| filingDate | 2019-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92668d4bc063334fee22c8c4f51ba5db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f41d5aefc67745bf92f25df09c2bcd2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59898fbcecbaa7bfb7eaea2a5a2f42c4 |
| publicationDate | 2019-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109666010-A |
| titleOfInvention | A kind of synthetic method of Rubrolide compound |
| abstract | The invention discloses a method for synthesizing Rubrolide compounds, comprising the following steps: (1) under the action of phosphoric acid, substituted phenylacetaldehyde and glyoxylic acid are reacted to obtain intermediate 1; (2) the intermediate 1 is reacted with NaBH 4 The reduction reaction is carried out, and the reduction reaction product is then dehydrated with concentrated sulfuric acid to obtain the intermediate 2; (3) under the action of a base, the intermediate 2 and the substituted benzaldehyde are refluxed to obtain the target product. The synthetic method of the Rubrolide compound provided by the invention adopts substituted phenylacetaldehyde, glyoxylic acid, phosphoric acid, NaBH 4 and concentrated sulfuric acid as raw materials, the raw materials are cheap and easy to obtain, the synthetic method is simple and the reaction is mild, which is similar to the traditional synthetic method. It not only avoids expensive raw materials and precious metal catalysts, greatly reduces production costs, but also avoids harsh reaction conditions; and the reaction conditions are mild, the operation is simple, environmentally friendly, and the solvent is easy to recover and apply, which is suitable for industrial production. |
| priorityDate | 2019-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.