| abstract |
The invention discloses a PEEK bone graft attached with tricalcium phosphate sustained-release antibiotics and a preparation method thereof. The method comprises the following steps: (1) pulverizing and extracting the polyether ether ketone, filtering, collecting and washing the solid phase product; (2) adding the solid phase product to an acid solution to soak, filter, and then extruding the solid product to form; (3) preparing a bioactive layer; (4) extruding the product obtained in step (3) onto the product obtained in step (2) to form a bioactive layer with a thickness of 2-3 mm, cooling to room temperature, and placing it in an antibiotic solution Soak for 1 to 2 hours. The PEEK bone graft prepared by the invention can directly act on the diseased part by carrying the medicine, without blood to carry the medicine and antibiotics to the diseased area, and can obtain a continuous higher medicine concentration in some parts, while maintaining a lower blood medicine concentration, To prevent the toxic side effects of systemic medication. |