| abstract |
A method for synthesizing 2-arylbenzopyrone flavonoid derivatives relates to a method for synthesizing a compound, which is suitable for the synthesis of 2-arylbenzopyrone flavonoid derivatives containing different substituents. The invention aims to solve the technical problems of low yield, long reaction period, complicated post-processing and high operation difficulty in the existing synthetic method of ketone flavonoid derivatives. The method is as follows: 1. preparing β-propanedione compound; 2. preparing flavonoid compound 2-arylbenzopyrone. The method completes esterification and rearrangement in one step, is simple and practical, reduces the intermediate links of the reaction, saves the separation and purification of intermediate products, improves the utilization rate of raw materials, reduces the reaction temperature, shortens the reaction time under microwave radiation, reduces the The amount of solvent used, the post-processing is relatively simple, the yield is relatively high, and there are no by-products. Moreover, it can also react in the presence of a small amount of water, the reaction is easy to operate, and is suitable for industrial production. The present invention belongs to the technical field of compound synthesis. |