http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109651211-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-28 |
| filingDate | 2018-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109651211-B |
| titleOfInvention | Method for preparing 2, 3-dimercaptopropanesulfonic acid sodium salt |
| abstract | The invention belongs to the technical field of drug synthesis, and particularly relates to a method for preparing sodium 2, 3-dimercaptopropanesulfonate. The method takes sodium allylsulfonate as an initial raw material, and the sodium allylsulfonate is subjected to bromination reaction, sulfhydrylation reaction, lead salt forming reaction, deleading reaction and refining to obtain the high-content sodium 2, 3-dimercaptopropanesulfonate, wherein the total yield is over 23.2 percent, particularly, the yield can be greatly improved when a zinc powder reduction step is added after hydrolysis, the total yield can reach 35 to 41.5 percent, and the content of the refined sodium 2, 3-dimercaptopropanesulfonate is over 99 percent. The invention adopts potassium thioacetate as sulfhydrylation agent, hydrolyzes under strong acid condition, and uses dilute sulphuric acid to remove lead after lead is formed, so that hydrogen sulfide which is a highly toxic gas and has influence on environment is avoided being used or generated in the whole reaction and treatment process, the working condition is improved, the discharge of three wastes is reduced, and the production efficiency is improved. |
| priorityDate | 2018-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.