http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109651203-B

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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06
filingDate 2019-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-109651203-B
titleOfInvention Preparation method of DP-IV inhibitor aulogliptin intermediate
abstract The present invention provides a method for preparing an alogliptin intermediate. The acid propargyl ester is reacted to obtain the product C 1-(2,5-difluorophenyl)-1-oxopent-4-alkyn-2-ylcarbamate. The invention takes a unique approach, selects a specific aulogliptin intermediate as the research direction, provides an efficient process, and the one-step reaction yield can be as high as 96%.
priorityDate 2019-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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