| abstract |
The invention discloses a medical hydrogel which is formed by in-situ crosslinking of aldehyde-group-terminated star-shaped multi-arm polyethylene glycol and a polyamino compound, wherein the aldehyde group and the star-shaped multi-arm polyethylene glycol are connected by ether bonds, amido bonds, urethane bonds, imine bonds or urea bonds, the molar ratio of the amino group in the polyamino compound to the aldehyde group in the aldehyde-group-terminated star-shaped multi-arm polyethylene glycol is 0.4-4.4:1, the polyamino compound is polylysine or a mixture of polylysine and polyethyleneimine, and the molar ratio of the polylysine to the polyethyleneimine is 2-30: 3. The hydrogel disclosed by the invention is quick in gelling, has long-term stability in aqueous solution, still has good swelling performance and stability after multiple irradiations, and can be used as a medical radiotherapy protective gasket for radiation protection. |