abstract |
The present invention relates to heterocyclic compounds of formula (I) capable of modulating CFTR activity, wherein all variables are as defined in the specification. The present invention further provides methods of preparing the compounds of the present invention and their therapeutic uses. The present invention further provides methods for the preparation of the compounds, their medical uses, and in particular their use for the treatment and management of diseases or disorders including cystic fibrosis and related disorders. |