http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109641054-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-177 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-544 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-546 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-544 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 2017-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109641054-B |
| titleOfInvention | A photosensitizer-peptide conjugate comprising a cleavable linker and a photodynamic diagnostic or therapeutic composition comprising the conjugate |
| abstract | The present invention relates to a photodynamic diagnostic or therapeutic conjugate in which a peptide binds to a photosensitizer through intracellular cleavable linkage, and a photodynamic diagnostic or therapeutic composition comprising the conjugate. Since the fluorescence signal and reactive oxygen generation ability of the photosensitizer in the conjugate of the present invention is quenched, the fluorescence signal and reactive oxygen are not generated during normal tissue or blood circulation, but are selectively ingested. After entering into the target cell, the linker is decomposed in the cell, so that the distance between the tryptophan contained in the peptide and the photosensitizer becomes larger, and the extinction effect disappears, so a strong fluorescent signal is generated and actively generated. reactive oxygen. Accordingly, the conjugate according to the present invention has high tissue permeability and is very safe in normal cells. On the contrary, it has a high photodynamic therapeutic effect in target cells, so that a higher labeling signal rate against the background can be obtained. diagnostic images. |
| priorityDate | 2016-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 251.