http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109627231-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C29-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C33-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-00 |
| filingDate | 2018-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109627231-B |
| titleOfInvention | Preparation method and application of chiral 1, 3-dioxane compound |
| abstract | The invention discloses a preparation method and application of chiral 1, 3-dioxane compounds, wherein racemic 2-substituted-2-vinyl oxetane compounds are used as raw materials, and the raw materials are reacted with formaldehyde under the catalysis of a chiral palladium complex generated by coordination of a palladium source and a chiral ligand as a catalyst to prepare the chiral 1, 3-dioxane compounds. The chiral compound provided by the invention is a precursor of a functionalized chiral 1, 3-diol compound, can be flexibly and conveniently subjected to functional transformation, and is an important chiral molecular building block for preparing chiral drugs and intermediates. The preparation method provided by the invention is an asymmetric cycloaddition reaction catalyzed by palladium, and has the advantages of high catalytic activity, high regioselectivity and enantioselectivity, mild reaction conditions and convenient and easily obtained reaction raw materials. |
| priorityDate | 2018-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.