| abstract |
The embodiment of the present invention provides a reaction device for benzylic bromination of biphenyl derivatives, comprising a first storage tank, a second storage tank, a mixer, a photocatalytic temperature-controlled pipeline reactor and a light source; The storage tank and the second storage tank are communicated with the feed port of the mixer; the reactor includes at least one reaction unit; each reaction unit is composed of at least three layers of transparent flat plates superimposed, and the adjacent two layers of flat plates are respectively A group of channels are respectively provided; in each group of channels, at least one group of material channels and at least one group of temperature control channels are included; the material channels are used for bromination reaction; the temperature control channels are used to control the reaction temperature; channel of visible and/or ultraviolet light. By adopting the device and method of the present invention, the light absorption efficiency of the bromination reaction is high, the use of free radical initiators is avoided, and the reaction rate is also improved; by controlling the number and connection mode of the reaction units, the requirements of different reaction amounts can be met, which is convenient and convenient. Adjust production scale. |