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filingDate 2019-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80581d57a6cf9decc8fd44c4e1baaa7f
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publicationDate 2019-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-109621006-A
titleOfInvention Preparation method of anti-infective bioactive coating on the surface of 3D printed porous titanium stent
abstract The invention discloses a method for preparing an anti-infection bioactive coating on the surface of a 3D printed porous titanium stent, comprising the following steps: (1) preparing a porous titanium stent by using a 3D printing technology; (2) using a sandblasting process for surface pretreatment, and then An annealing process was used to form a smooth surface morphology on the surface of the porous titanium scaffold; (3) the porous titanium scaffold was immersed in sodium hydroxide solution and oscillated; (4) rinsed with deionized water or distilled water for several times, and then rinsed in distilled water and dilute hydrochloric acid respectively. Soak in the solution, then dry and heat up. After holding for a certain period of time, the room temperature is cooled down with the furnace; (5) Configure simulated body fluid, add vancomycin to the simulated body fluid, soak the porous titanium stent in the simulated body fluid and oscillate at a constant temperature. The surface of the titanium stent was obtained with a hydroxyapatite anti-infective bioactive coating carrying vancomycin. The invention can significantly improve the osseointegration, osteoconduction and osteoinduction properties of the porous titanium support, and achieve the purpose of preventing postoperative infection.
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