| abstract |
The invention provides a targeted doxorubicin-loaded supramolecular hydrogel, which is characterized in that it is composed of α-cyclodextrin, Pluronic F127, DOX-2N-β-CD and FA-2N-β-CD The reaction is obtained. The method for preparing the targeted doxorubicin-loaded supramolecular hydrogel is characterized in that, comprising the steps of: weighing DOX-2N-β-CD, Pluronic F127 and FA-2N-β-CD in In the reactor, deionized water is added, and the reaction is stirred; α-CD is added, and the reaction is continued to be stirred. After the reaction is completed, the reaction system is allowed to stand for 10-15 h to obtain a targeted adriamycin-loaded supramolecular hydrogel. In the present invention, the drug molecules folic acid and doxorubicin are respectively loaded in the hydrogel network in the form of covalent bonds, which can not only reduce the toxic and side effects of the drug doxorubicin, but also effectively improve the targeting property of the hydrogel. |