| abstract |
The invention relates to a C-H activation/cyclization reaction using water as a solvent, sulfur ylide as a carbene donor, and transition metal catalysis to efficiently form a C-C bond on an aromatic (hetero) ring, and cyclically synthesize isoquinoline derivatives A new method for green synthesis of substances. Compared with the traditional method, the method has easy-to-obtain raw materials, simple steps, avoids the use of toxic organic solvents, is a mild, fast, simple, effective and environmentally friendly method for preparing isoquinoline parent rings, and has broad application. prospect. |