http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109602952-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-622 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-22 |
| filingDate | 2018-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109602952-B |
| titleOfInvention | Long-acting slow-release cell scaffold and preparation method and application thereof |
| abstract | The invention discloses a long-acting slow-release cytoskeleton, which comprises medicine-cytokine protein, silk fibroin and composite protein, wherein the medicine-cytokine protein is a cytokine slow-release microsphere formed by mixed coating of the silk fibroin, the composite protein is coated on the outer layer of the cytokine slow-release microsphere, the silk fibroin is self-assembled silk fibroin regulated and controlled by calcium salt, and the composite protein comprises gelatin which can escape immune attack of an organism and can be degraded and metabolized by cells; the invention forms cell factor slow release microspheres by silk fibroin coating, then coats composite protein which can be degraded and utilized by cells, and can realize long-term slow release of the medicine for 3-5 months; the hybrid of hydrogel formed by the adopted composite protein has stronger mechanical tolerance than that of pure collagen and chondroitin sulfate; and has good homology, long drug slow release period, better mechanical tolerance and metabolic activity of cartilage tissue in the process of being converted into cartilage matrix. |
| priorityDate | 2018-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 105.