http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109602922-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K101-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2018-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109602922-B |
| titleOfInvention | Long-persistence nanomaterials with internal irradiation and photodynamic dual therapy and dual-modal imaging effects and preparation method thereof |
| abstract | The invention relates to a long afterglow nanomaterial with the functions of internal irradiation, photodynamic dual treatment and dual mode imaging and a preparation method thereof. It is prepared by the following steps: 1. Preparation of ZnGa 2 O 4 : Cr-ZnPc(COOH) 4 : 1, 1, preparation of NaOH solution; Ⅱ, reaction of ZnGa 2 O 4 : Cr powder with NaOH solution; Ⅲ, centrifugation, precipitation drying in an oven, collecting ZnGa 2 O 4 : Cr-OH powder for use; VI, reconstituting to obtain a reconstituted solution; 2, I, activating the ZnPc(COOH) 4 activation solution; 3, I, adding the reconstituted solution to ZnPc(COOH) 4. Activation solution; II, add methoxy PEG5000 and hydroxyphenylpropionate-N-hydroxysuccinimide, and stir in the dark; 4, centrifuge, then add DMF to redissolve and centrifuge again, repeat after drying, and collect ZnGa 2 O 4 : Cr-ZnPc(COOH) 4 powder is placed in a LEP tube, protected from light for use; 2, 1, the iodogen coating tube is prepared; 2, the prepared ZnGa 2 O 4 : Cr-ZnPc(COOH) 4 powder and the corresponding mGi 131 I of /uGi was added into the iodogen coating tube together, and the reaction was shaken, and 131 I-ZnGa 2 O 4 : Cr-ZnPc(COOH) 4 was obtained at this time. It has the advantages of internal irradiation and photodynamic dual therapy, SPECT and IVIS dual-modal imaging, good chemical stability and biodistribution, and high specific activity. |
| priorityDate | 2018-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.