| abstract |
The present invention provides a modified release formulation such as a solid oral dosage form, comprising: a core composition comprising Compound (I) and/or a pharmaceutically acceptable salt thereof; a bottom coating layer coating the core composition, the The bottom coating layer comprises polyvinyl alcohol and/or hydroxypropyl methylcellulose; and an enteric coating layer encapsulating the bottom coating layer and the core composition, the enteric coating layer comprising at least A polymer selected from the group consisting of acrylic acid/methacrylic acid/ethacrylic acid homopolymers and copolymers thereof, cellulose derivatives and polyvinylpyrrolidone; the invention also provides for the administration of Bruton's tyrosine kinase using said formulation (BTK) inhibitor method. |