http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109589419-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6911 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-665 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 |
| filingDate | 2019-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2023-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2023-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109589419-B |
| titleOfInvention | Targeted temperature-controlled polysaccharide-loaded long-circulation liposome-microbubble complex drug delivery system and preparation method thereof |
| abstract | The invention discloses a targeted temperature-controlled polysaccharide-loaded long-circulation liposome-microbubble complex drug delivery system and a preparation method thereof. The present invention uses the double-emulsification solvent volatilization method to prepare the polysaccharide-loaded thermosensitive liposome and Taking the perfluoropropane microbubbles prepared by the film dispersion method as an example, the liposomes and microbubbles were connected by the biotin-avidin coupling method to prepare the polysaccharide-loaded thermosensitive liposome-microbubble complex. The present invention uses the complex as a drug delivery system, and can utilize the targeted blasting of microbubbles and the local temperature control effect of thermosensitive liposomes to realize the efficient release of drugs in local tissues in sub-high temperature fields, and improve the bioavailability of drugs. And reduce the residual of thermally ablated tumor. |
| priorityDate | 2019-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 122.