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publicationDate 2019-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-109576340-A
titleOfInvention In vivo distribution and biosafety evaluation method of fluorescent nanoparticles in vinegar
abstract The invention discloses a method for evaluating the in vivo distribution and biological safety of fluorescent nanoparticles in vinegar. The concentration of fluorescent nanoparticles in vinegar with a survival rate of 50% to 90% of NRK cells was used as a potentially dangerous concentration to detect cell apoptosis; a safe concentration with a cell survival rate of more than 90% was used for NRK cell imaging experiments to observe the concentration of vinegar in vinegar. Distribution of fluorescent nanoparticles in cells; BALB/c mice were gavaged with fluorescent nanoparticles in vinegar, and after different time treatments, the distribution of fluorescent nanoparticles in vinegar in mice was observed; finally, the hemolysis experiment was carried out. Determination of the degree of destruction of red blood cells in mice by vinegar fluorescent nanoparticles. The invention provides a reliable scientific basis for the safety of fluorescent nanoparticles in vinegar, and also provides a reference for the safety evaluation of other nanomaterials.
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