http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109576313-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b9c0aeb326c10100185fc3a11b7a1be |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-22 |
| filingDate | 2017-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6621eef24771b841dbb83f7bfa61f032 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d9a58225184f7d70dd53809dd31a917 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbdf87e1d2bce1649fa2bc9215e4e6c0 |
| publicationDate | 2019-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109576313-A |
| titleOfInvention | A kind of method for preparing (S)-2-chloro-1-(3-hydroxyphenyl)ethanol |
| abstract | The invention relates to the preparation of chiral alcohol by an enzymatic method, and belongs to the field of genetic engineering technology for preparing pharmaceutical intermediates. A method for preparing (S)-2-chloro-1-(3-hydroxyphenyl) ethanol, wherein α-chloro-3-hydroxyacetophenone is converted into (S)-2 under ketone reductase catalysis -Chloro-1-(3-hydroxyphenyl)ethanol. The method is used to catalyze the preparation of (S)-2-chloro-1-(3-hydroxyphenyl) ethanol by screening out a ketoreductase with a specific amino acid sequence, so as to achieve a conversion rate of more than 99% of the substrate, and the prepared product ee The value is 100%. In addition, the subsequent product separation and purification is simple, the post-processing cost is low, the whole process flow is highly environmentally friendly, and the atom utilization rate is high. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114958927-A |
| priorityDate | 2017-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 460.