| abstract |
The invention provides a pharmaceutical composition of a substituted pyrazolo[1,5-a]pyrimidine macrocyclic compound and use thereof. The pyrazolo[1,5-a]pyrimidine macrocyclic compound is such as The compound represented by formula (Aa), or a pharmaceutically acceptable salt, prodrug, hydrate or solvate, crystal form, stereoisomer or isotopic variant thereof. The compounds of the present invention are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases. |