http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109574998-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 |
| filingDate | 2017-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109574998-B |
| titleOfInvention | Synthetic method of pitavastatin calcium intermediate |
| abstract | The invention discloses a synthesis method of a pitavastatin calcium intermediate, which comprises the following steps: reacting 2-cyclopropyl-4- (4-fluorophenyl) quinoline-3-bromomethyl with trimercapto-s-triazine under the catalysis of sodium hydroxide to obtain a substance A; then oxidizing by the action of an oxidant to obtain a substance B; and then reacts with (4R-Cis) -6-formyl-2, 2-dimethyl-1, 3-dioxane-4-tert-butyl acetate under the catalysis of sodium hydride to obtain the pitavastatin calcium intermediate. The method has the advantages of cheap and easily-obtained raw materials, novel route, good atom economy, environmental protection, mild and controllable reaction conditions, convenient and simple operation, simple purification treatment, suitability for industrial production, good stereoselectivity, high yield and good purity of the pitavastatin calcium intermediate. |
| priorityDate | 2017-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.