http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109574983-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 |
| filingDate | 2017-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109574983-B |
| titleOfInvention | Preparation method of rotigotine |
| abstract | The invention discloses a preparation method of rotigotine, which comprises the following steps: s1, carrying out amination reduction reaction on the 5-methoxy-2-tetralone solution, tert-butyl sulfenamide, a catalyst and sodium borohydride to obtain a substance A; s2, carrying out alkylation reaction on the solution of the substance A, bromopropane and a basic catalyst to obtain a substance B; s3, reacting the substance B with a hydrochloric acid methanol solution to obtain a substance C; s4, reacting the substance C, 2- (2-bromoethyl) thiophene, potassium carbonate and N, N-dimethylformamide to obtain a substance D; s5, reacting the substance D, acetic acid and hydrobromic acid to obtain rotigotine. The method has the advantages of simple operation, high yield, mild reaction conditions, environmental protection and high purity of the prepared rotigotine, and is suitable for large-scale industrial production. |
| priorityDate | 2017-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.