http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109574869-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2018-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109574869-B |
| titleOfInvention | Preparation method of oseltamivir phosphate |
| abstract | The invention discloses a preparation method of oseltamivir phosphate, which comprises the following steps: firstly, reacting an intermediate shown in a formula (IV) with palladium acetate, triphenylphosphine and N, N-dimethyl barbituric acid in a solvent, and removing allyl to obtain an intermediate shown in a formula (III), wherein the equivalent ratio of the intermediate shown in the formula (IV), the palladium acetate, the triphenylphosphine and the N, N-dimethyl barbituric acid is 1:0.01:0.04:1.2, secondly, treating the intermediate shown in the formula (III) with an acid, removing tert-butyl to obtain oseltamivir free base shown in the formula (II), and finally, reacting the oseltamivir free base with phosphoric acid in the solvent, and crystallizing and purifying. According to the oseltamivir phosphate obtained by the method, the residual amounts of the main heavy metals such as palladium, arsenic, cadmium, cobalt, copper, mercury, lithium, nickel, lead, antimony, titanium, vanadium and the like are within a limit range, and accord with the ICH standard. |
| priorityDate | 2018-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.