http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109568607-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-103 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-26 |
| filingDate | 2018-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109568607-B |
| titleOfInvention | Gadolinium-based metal fullerene water-soluble nitrene derivative and preparation method and application thereof |
| abstract | The invention discloses a gadolinium-based metal fullerene water-soluble nitrene derivative and a preparation method and application thereof. The gadolinium-based metal fullerene water-soluble nitrene derivative is prepared from paramagnetic gadolinium-based metal fullerene Gd a N b @C 2n With azide N 3 (CH 2 ) m NH 2 Or N 3 (CH 2 ) m‑1 COOH is prepared through nitrene reaction, and the structural general formula is as follows: gd (Gd) a N b @C 2n [N(CH 2 ) m NH 2 ] x Or Gd a N b @C 2n [N(CH 2 ) m‑ 1 COOM] x In the structural general formula, a is 1-3; b is 0-3; n is 30-45; m is 2-6; x is 8-30; m is H, NH 4 Na or K. The invention provides a method for preparing gadolinium-based metal fullerene water-soluble nitrene derivatives through nitrene reaction. The gadolinium-based metal fullerene water-soluble nitrene derivative has good water solubility and good paramagnetic property, can be used as a magnetic resonance imaging contrast agent, has a very obvious contrast enhancement effect when being used for MRI image imaging, and has an important application prospect in medical diagnosis and treatment, particularly in MRI image-guided diagnosis and treatment. |
| priorityDate | 2018-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.