http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109568595-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-548 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 2019-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109568595-B |
| titleOfInvention | Nucleic acid-drug conjugates, drug delivery systems, methods of making and uses thereof |
| abstract | The invention belongs to the field of biomedicine, and particularly discloses a nucleic acid-drug conjugate based on phosphorothioate modified nucleic acid, a drug delivery system and preparation methods thereof. The nucleic acid-drug conjugate is formed by combining phosphorothioate groups in phosphorothioate modified nucleic acids with groups which are modified on drug molecules and can have electrophilic reaction with the phosphorothioate groups, and the nucleic acid-drug conjugate can be self-assembled into drug-containing nano-carriers in various forms for drug delivery by selecting different nucleic acid sequences including functional nucleic acids. Compared with the prior art, the method can be achieved by a simple solid-phase synthesis technology, the grafting sites and the assembly form of the drug molecules on the nucleic acid skeleton can be accurately controlled, and the method has universality on chemotherapeutic drugs; the invention can obviously improve the physicochemical property and in vivo distribution property of the chemotherapeutic drug and promote the treatment effect thereof, and can also realize the combined treatment of gene therapy and chemotherapy. |
| priorityDate | 2019-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.