| abstract |
Preparation and application the invention discloses a kind of polycation macromolecular prodrug for the nano composite system of gene target transmitting.The compound system is to form nano composite system by the high molecular materials such as polycation, targeting group, anti-tumor drug and target gene.Anti-tumor drug, targeting group are coupled to polycation, synthetic macromolecule prodrug by chemical bond, then prepare macromolecular prodrug nanometer system using self-assembly method by the advantage of the present invention comprehensive administration nano-drug administration system and macromolecular prodrug.Target gene is wrapped up in self assembling process, is given target gene and is effectively protected, gene is avoided to be degraded by enzymes.The present invention is realized the advantages of drug transmits altogether with gene, combines gene therapy and chemotherapy, is had a good application prospect in terms of oncotherapy using polycation macromolecular prodrug as genophore. |