http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109536503-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-31 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115 |
| filingDate | 2018-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109536503-B |
| titleOfInvention | Aptamer combined with CD133 protein in targeted manner and screening method and application thereof |
| abstract | The invention provides an aptamer of targeted binding CD133 protein and a screening method and application thereof, wherein the sequence of the aptamer is shown as SEQ ID NO.1, the aptamer of targeted binding CD133 protein is screened from a ssDNA library by adopting a cell screening method, the screened ssDNA is detected by a high-throughput sequencing method, and finally, the aptamer AP-1-M is selected by analyzing the stability and the affinity of the obtained sequence by methods such as flow cytometry and the like. Then, an immunofluorescence method proves that the aptamer AP-1-M can be specifically combined with the CD133 protein in a targeted mode and is combined with ATC cells expressing the CD133 protein to achieve the effect of targeted delivery, and a new thought and method are provided for ATC targeted therapy. |
| priorityDate | 2018-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.