http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109536461-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-32134 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-32121 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 |
| filingDate | 2018-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109536461-B |
| titleOfInvention | O-type foot-and-mouth disease virus mutant strain and preparation method and application thereof |
| abstract | The invention provides an O-type foot-and-mouth disease virus mutant strain, a preparation method and application thereof, belonging to the technical field of vaccine candidate strains. The O type foot-and-mouth disease virus mutant strain takes rHN strain as a mother strain, and the following amino acids in the G-H ring of VP3 protein are mutated: aspartic acid 173 is mutated to asparagine, valine 174 to glutamic acid and asparagine 179 to cysteine. The virus mutant is genetically stable and acquires the ability of caveolin-mediated infection of CHO-K1 cells. The results show that compared with the maternal virus strain, the cross protection capability of the virus mutant strain for inducing neutralizing antibodies of foot-and-mouth disease viruses generated by organisms is remarkably improved, and the excellent broad-spectrum antigen is shown. The vaccine prepared by inactivating the virus mutant strain can be used for preventing the infection of the O-type foot-and-mouth disease virus. |
| priorityDate | 2018-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.