http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109528737-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-635 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-635 |
| filingDate | 2018-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109528737-B |
| titleOfInvention | Polysaccharide sulfate anti-tumor nano preparation and preparation method thereof |
| abstract | The invention relates to an alginic sodium diester anti-tumor nanometer preparation and a preparation method thereof, and the preparation comprises the following components by mass: the mass ratio of the polysaccharide sulfate to the polyvinylpyrrolidone is 2 ‒ 5: 5; the content of polysaccharide sulfate is 15 ‒ 50%; the content of the adriamycin hydrochloride and the celecoxib is 40 ‒ 80%; the balance being water; the polysaccharide sulfate has the intrinsic viscosity of 9.0 ‒ 14.0.0 and the organic sulfur content of 9.0 ‒ 13.0.0 percent; the mass ratio of the adriamycin hydrochloride to the celecoxib is 1/10-1/2. The invention utilizes the surface activity and crystallization inhibiting performance of the polysaccharide sulphate sodium alginate as a stabilizer to prepare a nano preparation of a hydrophobic or amphiphilic anti-tumor medicament, so as to improve the solubility of the medicament, improve the bioavailability of the medicament, enhance the curative effect of the medicament, reduce the toxic and side effects of the medicament and further better apply the polysaccharide sulphate sodium alginate in clinical application of tumor treatment. The invention can obviously inhibit the in-vivo and in-vitro growth and metastasis of tumors and provides scientific basis for the development of the application of the polysaccharide sulphate in the aspects of new dosage forms of antitumor drugs and the like. |
| priorityDate | 2018-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 104.