| abstract |
The invention discloses the application of ellipticine in the preparation of antibacterial and anti-inflammatory drugs. Through RNA-seq transcriptome analysis of bacterial-infected human cells, based on co-expression pathways and drug gene set enrichment analysis methods, a list of candidate drugs with antibacterial and anti-inflammatory effects was obtained, and several marketed drugs with antibacterial and anti-inflammatory effects were found. , ellipticine, which has not been found to have antibacterial and anti-inflammatory effects before, is among them, and it has been verified at the cellular level that its effect is stronger than that of common antibacterial and anti-inflammatory drugs metronidazole and gentamicin. Therefore, ellipticine can be applied For the preparation of antibacterial and anti-inflammatory drugs. |