| abstract |
Described herein is a 5'-cyclic phosphonate-modified nucleotide and oligonucleotides such as RNA interference (RNAi) agents comprising the 5'-cyclic phosphonate-modified nucleotide. The RNAi agents described herein with double-stranded or single-stranded oligonucleotides comprising 5'-cyclic phosphonate-modified nucleotides can be used to modulate gene expression as well as therapeutic, diagnostic, target validation, genomic development applications. RNAi agents and single-stranded antisense oligonucleotides comprising 5'-cyclic phosphonate-modified nucleotides can be used to treat diseases or disorders responsive to inhibition of gene expression or activity in cells, tissues, or organisms. |