| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9126 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-48721
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-4146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-07007 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-414
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 |
| filingDate |
2015-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a089eda29178873a942db734a8af158f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5c6d5cd9fadf6b3ce86ece1c98df350
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04b3497f0644eb15c20eb1a99a7d6a59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c90312319a02779ff17338a0ecc67cfa |
| publicationDate |
2019-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109517878-A |
| titleOfInvention |
Detection of nucleic acid polymerase conformational changes using nanotubes |
| abstract |
The present invention provides methods and compositions for detecting changes in the conformation of nucleic acid polymerases, the methods involving attaching a nucleic acid polymerase non-covalently attached to a single-walled carbon nanotube (SWNT) to a first nucleotide or a third a nucleotide analog is contacted with the template; and the conformationally changed nucleic acid polymerase is detected by measuring the first conductance change in the SWNT between the nucleic acid polymerase and the conformationally changed nucleic acid polymerase. The method is suitable for the sequencing of polynucleotides. |
| priorityDate |
2014-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |