| abstract |
The present invention provides aminoquinazolinone and aminoisoquinolinone derivatives. It has been confirmed by many experiments that the synthesized compounds have excellent inhibitory effects on PI3Kα and PI3Kγ, and most of the compounds have good inhibitory effects on PI3Kα. It has a significant inhibitory effect, and shows a potent growth inhibitory effect on tumor cell lines such as PIK3CA-mutated human breast cancer cell line (MCF7). Therefore, the aminoquinazolinone and aminoisoquinolinone derivatives of the present invention can be used in the preparation of anti-tumor and anti-inflammatory drugs, and can be used as PI3Kα inhibitors in the treatment of human or animal cell proliferation-related tumors The medicament includes any one or any multiple of derivatives and pharmaceutically acceptable salts and solvates thereof and pharmaceutically acceptable carriers. The compounds of the present invention have general formulas a and b. |