http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109513014-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 |
| filingDate | 2018-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109513014-B |
| titleOfInvention | Tubulin self-assembly gadolinium nanometer nuclear magnetic resonance contrast agent and preparation method thereof |
| abstract | The invention relates to a nuclear magnetic resonance contrast agent, in particular to a tubulin self-assembly gadolinium nanometer nuclear magnetic resonance contrast agent and a preparation method thereof, belonging to the field of biomedical materials. Adding gadolinium chloride into Tubulin, wherein the concentration of the Tubulin is 2mg/ml, the addition amount of the gadolinium chloride is required to be 1mM, adjusting the pH value of the system to 7.5 by using dilute hydrochloric acid and sodium hydroxide solution, placing the system in a shaking table, oscillating the system, taking out the system, and performing ultrafiltration by using an ultrafiltration tube to assemble the Tubulin and gadolinium ions into a gadolinium @ Tubulin (Gd @ Tubulin) nano system. The tubulin self-assembled gadolinium-based nanoparticle prepared by the invention has the advantages of simple preparation, high safety, long in-vivo circulation time and the like, and is successfully applied to in-vivo magnetic resonance imaging. The novel tubulin self-assembled gadolinium-based nanoparticle synthesized by the method has wide application prospect in the field of biomedical basic research as a magnetic resonance contrast agent. |
| priorityDate | 2018-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.