http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109503568-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2018-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109503568-B |
| titleOfInvention | Preparation method of dasatinib |
| abstract | The invention relates to a preparation method of dasatinib, which comprises the following steps: reacting ethyl 3-oxopropionate with 2-chloro-6-methylaniline under an alkaline condition, adding a solvent in which copper bromide is dissolved for reaction, adding thiourea, and cyclizing under a catalyst to obtain 2-amino-N- (2-chloro-6-methylphenyl) thiazole-5-formamide; and then synthesizing the dasatinib by the 4, 6-dichloro-2-methylpyrimidine, N-hydroxyethyl piperazine and 2-amino-N- (2-chloro-6-methylphenyl) thiazole-5-formamide in a one-pot method under the action of alkali and ionic liquid 1-butyl-3-methylimidazole glycinate. The method has the advantages of mild conditions, simple steps, environmental friendliness and high yield, and is suitable for industrial production. |
| priorityDate | 2018-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.