http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109503564-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 |
| filingDate | 2018-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109503564-B |
| titleOfInvention | Process for preparing diastereoisomer 4-position substituted isoxazoline |
| abstract | A preparation method of diastereoisomer 4-substituted isoxazoline, relating to a preparation method of 4-substituted isoxazoline. The method aims to solve the problem that the existing method is difficult to simultaneously prepare two diastereoisomer 4-substituted isoxazolines with completely opposite configurations. The method comprises the following steps: chiral bisoxazoline is taken as a catalyst ligand, and Cu (OTf) is respectively taken 2 Or Ni (OTf) 2 As a metal center, bis-oxazoline derived from indenol is used as a chiral ligand to catalyze the reaction of acryloyl oxazolidinone and acryloyl-3, 5-dimethylpyrazole with diaryl nitrone, so as to prepare 4-substituted isoxazoline with completely opposite configuration. 100 percent of optically active cis-isoxazoline and trans-isoxazoline are obtained, and the enantioselectivity of the product is respectively up to more than 92 percent and 91 percent. Alcoholysis is carried out on the cis-4-substituted product and the trans-4-substituted product respectively to obtain a pair of optically pure diastereoisomers. The invention is used for preparing diastereoisomer 4-position substituted isoxazoline. |
| priorityDate | 2018-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.