http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109503553-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1044 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2018-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109503553-B |
| titleOfInvention | A kind of photoaffinity probe molecule based on VEGFR-2 inhibitor B14 and preparation method thereof |
| abstract | A kind of photoaffinity probe molecule based on VEGFR-2 inhibitor B14 and preparation method thereof, 4-bromopyridine-2-carboxylic acid and 1-(4-chloro-3-(trifluoromethyl)phenyl)-3 ‑(4‑(4,4,5,5‑tetramethyl‑1,3,2‑dioxaborolane‑2‑yl)phenyl)urea was subjected to Suzuki coupling reaction to obtain a Intermediate product of acid; linker containing photoaffinity group bis-aziridine and alkynyl group and intermediate product with monocarboxylic acid under the condensation of EDC·HCl to obtain photoaffinity based on VEGFR-2 inhibitor B14 and probe molecules. The preparation method of the B14 photoaffinity probe molecule of the present invention is simple, easy to realize, and has a high yield. The B14 small molecule photoaffinity probe of the present invention can be used to confirm the action target of B14 and to verify the feasibility of the photoaffinity labeling technology in confirming the small molecule target. |
| priorityDate | 2018-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.