http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109503511-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-56 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-56 |
filingDate | 2018-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-109503511-B |
titleOfInvention | Preparation method of dasatinib intermediate |
abstract | The invention relates to a preparation method of a dasatinib intermediate, which comprises the following steps: heating and refluxing 3-oxo ethyl propionate and 2-chloro-6-methylaniline under an alkaline condition, adding copper bromide, and heating and refluxing to obtain a compound 2; cyclizing the compound 2 and thiourea in a solvent PEG 400 to obtain the target product 2-amino-N- (2-chloro-6-methylphenyl) thiazole-5-formamide. The method has the advantages of mild conditions, simple steps, environmental friendliness and high yield, and is suitable for industrial production. |
priorityDate | 2018-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.