http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109503505-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d40285e27f4ed83b8728b0d477404958 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 |
| filingDate | 2019-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41939d330360ee14ddb52a3a39c30db3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79ce365fed767a61575b4d2a27948a04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1037281de16118d2b83bb79668a242b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6689033bcd9ef9a6b3663b5bc016fcf3 |
| publicationDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109503505-A |
| titleOfInvention | A kind of synthetic method of 5-substituted tetrazolium compounds |
| abstract | The invention discloses a method for synthesizing 5-substituted tetrazolium compounds. The process of the synthesis method is as follows: adding a nitrile compound represented by formula (I), sodium azide, nickel ferrite and Carboxylic acid ammonium-based ion exchange resin, and then adding an organic solvent to carry out cyclization reaction, after the reaction is completed, the reaction solution is filtered, acid washed, desolventized and recrystallized to obtain 5-substituted tetrazoles represented by formula (II) The compound, the yield is 85-95%, and the purity is greater than or equal to 99%; In formula (I) and formula (II), the substituent R 1 is phenyl, substituted phenyl, C1~C3 alkyl or amino; the substituent of substituted phenyl is methyl, methoxy, F or nitro . The method for synthesizing 5-substituted tetrazolium compounds of the present invention adopts the combined catalyst of nickel ferrite and ammonium carboxylate ion exchange resin for synergistic catalysis to immobilize the ammonium carboxylate group, which not only has good universality of reaction substrates, but also The reaction yield is high, and the catalyst is easy to separate and recycle, thereby reducing the production cost and the discharge of the three wastes. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112592322-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112592322-A |
| priorityDate | 2019-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.