| abstract |
This application discloses the methods of a kind of activation method of perfluoroalkyl carbon-halogen bond and pyridine synthesis derivative.Active pyridine-boron free radical that 4- cyanopyridine and connection pinacol borate reaction are generated, the carbon-halogen bond homolysis for being catalyzed perfluoroalkyl halide form perfluoroalkyl radical.To join pinacol borate, full-fluorine alkyl iodide (or bromide), 4- cyanopyridine and alkene are starting material, and reaction obtains the perfluoroalkyl and pyridine difunctionality dough pyridine derivative product of alkene.The present invention, which provides, to introduce alkene simultaneously for two important groups of perfluoroalkyl and pyridine, for the synthesis of pyridine derivatives, there is exploitation can be used for the value of commercial synthesis pyridine compounds and their new method. |