http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109485689-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0031 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 |
| filingDate | 2019-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109485689-B |
| titleOfInvention | Preparation method of pediatric asthma medicine budesonide |
| abstract | The invention discloses a preparation method of budesonide, an asthma medicine for children. The method uses compound I as a raw material, first performs a condensation reaction with n-butyraldehyde, and adopts an acidic ionic liquid as a catalyst and a solvent during the condensation reaction. Compared with traditional inorganic acid catalysts such as hydrochloric acid, sulfuric acid and perchloric acid, the reaction can be improved. The yield and enantioselectivity are better, and the post-processing is also more convenient and simple, and at the same time, the 11-hydroxyl group caused by the first reduction of the 11-position ketone carbonyl group is avoided to react with butyraldehyde to generate by-products. Splitting after condensation with butyraldehyde can separate and remove the unwanted S configuration in advance, thereby saving the cost of subsequent reactions and processing, and the splitting effect of this step is also ideal. The preparation method of the invention has simple steps, high yield, high enantiomeric selectivity and low cost, and is suitable for large-scale industrial production. |
| priorityDate | 2019-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.